# iRepertoire, Inc.

> iRepertoire offers TCR and BCR sequencing solutions for immune profiling and biomarker discovery.

Use this file as a source-bound company brief and routing layer for questions about iRepertoire, Inc.. Prefer the most specific linked page when a question is about a named product, assay, workflow, program, resource, or person.

## Company Overview

- Contact: [https://irepertoire.com/contact](https://irepertoire.com/contact)
- **Mission:** First to develop and commercialize immune repertoire sequencing technology and products
- **Focus area:** Immune adaptome sequencing
- **Subsidiary:** iRep China
- **Distribution reach:** Global
- **Core technology:** Proprietary multiplex PCR technology that amplifies the entire immune repertoire in a single tube for immune sequencing.
- **Workflow options:** dam-PCR Technology.
- **Assay menu:** iR-Complete Kits and ImmunoSight.
- **Application focus:** Autoimmune Disease, Infectious Diseases, Immuno-Oncology, and Immunotherapy Biomarker Discovery.

## Pages

### Company Pages

- [iRepertoire – TCR & BCR Sequencing for Immune Profiling](https://irepertoire.com/): iRepertoire offers TCR and BCR sequencing solutions for immune profiling and biomarker discovery. Use for: IRepertoire's products, services, and immune repertoire sequencing capabilities.
- [Who We Are – Our Story](https://irepertoire.com/investor/): Overview of iRepertoire as the first company to develop and commercialize immune repertoire sequencing technology and products. Use for: IRepertoire's background, history, and founding mission.
- [Distributors](https://irepertoire.com/distributors): Lists iRepertoire's global distributors and provides information about its subsidiary iRep China. Use for: IRepertoire distributors, regional availability, and iRep China.
- [Contact](https://irepertoire.com/contact/): iRepertoire's contact page for reaching the sales, support, and scientific team to discuss a project or request a quote. Use for: Contacting iRepertoire, requesting quotes, and starting a project consultation.

### Service Pages

**Bulk Immune Repertoire**

- [RepSeq+](https://irepertoire.com/repseq-plus/): Sensitive, quantitative, high-throughput assay combining multiplex PCR with NGS to analyze any combination of all seven adaptive immune receptor chains in a single reaction, supporting clinical development and drug discovery. Use for: Seven-chain TCR/BCR repertoire profiling, multiplex PCR sequencing, and biomarker/therapeutic development programs.
- [RepSeq IQ™](https://irepertoire.com/repseqiq/): Quantitative gDNA TCR/BCR AIRR sequencing assay that places immune repertoires on a standardized scale across samples, using direct-multiplex PCR with internal quantitative controls and housekeeping genes to determine total T/B cell quantity and per-clone frequency. Use for: IRepertoire's quantitative clonotype/cell-frequency sequencing, clinical data standardization, and iPSC transduction validation.
- [ImmunoSight](https://irepertoire.com/immunosight/): Fully customizable, targeted NGS assay that quantifies the expression of 150+ immunophenotype genes alongside AIRR sequence data at bulk or single-cell resolution, combining dam-PCR chemistry with gene-specific primers. Use for: Targeted immunophenotyping, tumor microenvironment characterization, and combined gene-expression/AIRR biomarker discovery.
- [RepSeq/RepSeq+ Submissions](https://irepertoire.com/repseq-sample-submission/): Sample submission form for customers sending samples for RepSeq or RepSeq+ bulk immune repertoire sequencing. Use for: Submitting samples for RepSeq or RepSeq+ sequencing services.

**Single Cell V(D)J**

- [iPair](https://irepertoire.com/ipair/single-cell-vdj-analysis/): Single-cell V(D)J sequencing service that captures physically paired full-length TCR or BCR chains from FACS-isolated single cells in a single low-volume reaction, powered by iRepertoire's arm-PCR technology. Use for: Single-cell paired-chain TCR/BCR discovery, rare clone identification, and lead candidate discovery for TCR and antibody therapeutics.
- [Hybridoma Sequencing](https://irepertoire.com/hybridoma-sequencing/): Antibody sequencing service for hybridoma cell lines that secures antibody IP, characterizes clones prior to functional testing, and supports recombinant antibody production, offered as a service or via the MonoVDJseq BCR library preparation kit. Use for: Hybridoma antibody sequencing, antibody sequence validation, and antibody library digitization.
- [iPair/iPair+ Submissions](https://irepertoire.com/ipair-submissions/): Sample submission form for customers sending single-cell samples for iPair or iPair+ sequencing services. Use for: Submitting samples for iPair single-cell V(D)J sequencing.

**Data Analysis**

- [Intellimune™ AIRR Data Analysis Platform](https://irepertoire.com/intellimune-data-analysis/): iRepertoire's Intellimune combines proven bioinformatics workflows, advanced visualization, and expert interpretation to transform AIRR sequencing data into reproducible, decision-ready immune insights, offered in Standard, Plus, Pro, and custom Discovery tiers. Use for: IRepertoire's data analysis service tiers, AIRR bioinformatics outputs, and repertoire intelligence deliverables.
- [Data Submission Form](https://irepertoire.com/data-submissions/): Submission form for customers sending previously generated sequencing data to iRepertoire for data analysis services. Use for: Submitting external data for Intellimune data analysis.

**Additional Services**

- [Sequencing](https://irepertoire.com/sequencing/): iRepertoire offers individualized immune sequencing services using Illumina platforms tailored to customer needs. Use for: IRepertoire's sequencing services and Illumina-based immune repertoire sequencing.
- [Sample Processing](https://irepertoire.com/sample-processing/): Sample preparation service covering cell thawing, staining and FACS sorting, single-cell plating, and nucleic acid extraction from blood, tissue, FFPE, and cryopreserved cells ahead of bulk repertoire or single-cell sequencing. Use for: Sample prep for immune repertoire sequencing, FFPE/tissue/cell processing, and FACS sorting and plating services.

### Technology Pages

- [arm-PCR Technology](https://irepertoire.com/arm-pcr): Overview of iRepertoire's proprietary arm-PCR multiplex PCR method for amplifying the entire immune repertoire in a single tube. Use for: IRepertoire's PCR amplification technology and immune repertoire sequencing methods.
- [dam-PCR Technology](https://irepertoire.com/dam-pcr): Overview of iRepertoire's dimer-avoided multiplex PCR method for comprehensive immune repertoire sequencing. Use for: IRepertoire's PCR amplification method and multiplex immune sequencing technology.
- [iRepertoire Multiplex PCR Technology](https://irepertoire.com/technology): Overview of iRepertoire's advanced PCR multiplexing technologies for immune repertoire sequencing and analysis. Use for: IRepertoire's core technologies, PCR multiplexing methods, and immune sequencing platforms.
- [Beyond Template Switching](https://irepertoire.com/beyond-template-switching): Explains how iRepertoire's multiplex PCR methods achieve greater sensitivity and bias reduction compared to template switch technology. Use for: IRepertoire's PCR methodology advantages over template switching for immune sequencing.
- [Beyond Template Switching – Multiplex PCR for Immune Sequencing](https://irepertoire.com/irepertoires-ir-complete-dual-index-primer-kits-for-rna-and-gdna): Explains how iRepertoire's multiplex PCR methods offer greater sensitivity and bias reduction compared to template switch technology. Use for: Multiplex PCR to template switching for immune repertoire sequencing.
- [iRepertoire Primer Systems](https://irepertoire.com/irepertoires-primer-systems): Overview of iRepertoire's patented multiplex PCR primer systems and enrichment chemistries used for immune repertoire sequencing. Use for: IRepertoire's PCR primer technology, enrichment chemistries, and immune sequencing methodology.

### Application Pages

- [Autoimmune Disease – Immune Repertoire Profiling](https://irepertoire.com/autoimmune): Describes iRepertoire's immune repertoire profiling services and technologies applied to characterizing autoimmune disease pathways. Use for: Immune repertoire sequencing for autoimmune disease research and pathway characterization.
- [Immunotherapy Biomarker Discovery](https://irepertoire.com/biomarker-discovery/): Describes how iRepertoire's proprietary multiplex PCR chemistry, multi-chain sequencing, and purpose-built bioinformatics deliver precise, reproducible immunotherapy biomarkers beyond PD-L1 and tumor mutational burden, including a case study detecting TCR repertoire remodeling and TIL product clone persistence in metastatic NSCLC patients. Use for: Immunotherapy biomarker discovery, TCR/BCR repertoire-based biomarkers, and precision immuno-oncology applications.
- [Immuno-Oncology Applications](https://irepertoire.com/immuno-oncology): Overview of iRepertoire's immune repertoire sequencing services and technologies applied to immuno-oncology research. Use for: IRepertoire's immuno-oncology sequencing products, services, and applications.
- [Infectious Diseases](https://irepertoire.com/infectious-diseases): iRepertoire application page covering immune repertoire sequencing services and products for infectious disease research. Use for: IRepertoire offerings applied to infectious disease immune profiling.

### Resource Pages

- [Learning Center](https://irepertoire.com/learning-center/): Hub of educational articles, guides, eBooks, product manuals, and technical resources on immune biology, repertoire sequencing basics, and iRepertoire's technology, organized into Immune Sequencing Basics, Technology, How to Plan Your Project, and a Useful Information Library. Use for: Immune sequencing education, sample submission and project-planning guidance, and iRepertoire product manuals/data sheets.
- [Publications](https://irepertoire.com/publications): A linked reference list of publications that have used iRepertoire immune sequencing technology, compiled in one resource. Use for: Research publications, citations, and studies using iRepertoire technology.
- [Posters](https://irepertoire.com/posters/): A library of scientific posters presented at conferences such as SITC, AACR, AAI, ISCT, and FOCIS, covering immune repertoire profiling, immunophenotyping, and related iRepertoire research. Use for: Conference posters, presented research, and scientific data supporting iRepertoire's technology.
- [Webinars & Videos](https://irepertoire.com/webinars-and-videos): A video library featuring webinars and animations about immune repertoire sequencing and the adaptome. Use for: Seeking iRepertoire educational videos, webinars, and immune repertoire animations.
- [B Cell and T Cell Structure and Function Overview](https://irepertoire.com/t-cell-and-b-cell-overview): An educational overview of B cell and T cell structure, function, and receptor features that provide antigen binding specificity. Use for: B cell and T cell structure, function, and receptor biology basics.
- [Cell-Sorting Guide for Single Cell Immune Sequencing](https://irepertoire.com/cell-sorting-guide): A guide helping users prepare for single cell immune sequencing by outlining cell-sorting steps available in-house or as an iRepertoire service. Use for: Cell sorting steps and preparation for single cell immune sequencing projects.
- [eBook 2: Intro to Immune Sequencing with iRepertoire](https://irepertoire.com/ebook-2-immune-sequencing): Landing page to download an eBook introducing immune repertoire sequencing and associated bioinformatics using iRepertoire. Use for: Asking about immune sequencing introductory resources and iRepertoire eBooks.

### Case Studies

- [iRepertoire Case Studies](https://irepertoire.com/case-studies/): Landing page listing case studies showcasing how iRepertoire technologies and services advance immune repertoire sequencing. Use for: Real-world examples and applications of iRepertoire products and services.
- [TCR Profiling for Immunotherapy Biomarker Discovery](https://irepertoire.com/biomarkers-case-study/): Case study on using high-resolution TCR sequencing to identify response biomarkers in patients with immunotherapy-resistant tumors treated with autologous TIL therapy. Use for: TCR profiling, TIL therapy biomarkers, and adaptive immune repertoire profiling in cancer immunotherapy.
- [Immunotherapy Case Study: Treatment Monitoring in Cancer](https://irepertoire.com/sitc-case-study-oncology/): Case study on how immune repertoire sequencing predicts and monitors pre- and post-treatment cancer outcomes across multiple disease pathologies using quantitative seven-chain dam-PCR analysis. Use for: Oncology treatment monitoring, pre/post-treatment immune repertoire sequencing, and cancer prognostic biomarkers.
- [Antibody Treatments for Infectious Disease – Case Study](https://irepertoire.com/antibody-case-study/): Overview of antibody-based immunotherapy approaches for infectious disease, from convalescent plasma to single-cell immune sequencing. Use for: Antibody treatments, convalescent plasma, and single-cell immune sequencing for infectious disease.
- [Reliable AIRRseq from FFPE Tissues](https://irepertoire.com/ffpe-case-study/): Case study demonstrating an optimized workflow — combining Covaris extraction, dam-PCR technology, and RepSeq+ seven-chain multiplex sequencing — for reliable, quantitative AIRR sequencing from challenging FFPE tissue samples. Use for: FFPE sample sequencing, RNA extraction from fixed tissue, and immune repertoire profiling in archival samples.
- [Therapeutic Response in Autoimmune Disease](https://irepertoire.com/case-study-therapeutic-response-autoimmune-disease/): Case study on using immune repertoire profiling to monitor immune cell diversity changes over time and post-therapy in RA and SLE patients, identifying biomarkers and predicting therapeutic response. Use for: Autoimmune therapeutic response monitoring, RA/SLE immune profiling, and biomarker-informed clinical study design.
- [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/case-study-cell-therapy/): Case study on using single cell TCR sequencing to predict and measure patient response to cell immunotherapy. Use for: Single cell TCR sequencing for cell therapy and immunotherapy response monitoring.

## Products

- [iR-Complete Kits](https://irepertoire.com/ir-complete-kits): Complete kits for sequencing the immune adaptome, based on iRepertoire's patented enrichment chemistries.

## Data and Platform

- [iPair Single Cell Analyzer](https://irepertoire.com/standard-data-analysis): Bioinformatics system for single cell immune sequencing data analysis, provided free with orders.
- [iRweb Bulk Repertoire](https://irepertoire.com/standard-data-analysis): Bioinformatics system for bulk immune repertoire sequencing data analysis, provided free with orders.
- [Intellimune Data Analysis](https://irepertoire.com/intellimune-data-analysis): Tiered AIRR data analysis platform (Standard, Plus, Pro, Discovery) covering diversity metrics, clonal dynamics, somatic hypermutation, and antigen-specificity modeling.

## Technology

- [arm-PCR](https://irepertoire.com/arm-pcr): Proprietary multiplex PCR technology that amplifies the entire immune repertoire in a single tube for immune sequencing.
- [dam-PCR](https://irepertoire.com/dam-pcr): Dimer-avoided multiplex PCR technology enabling high-level multiplexing and comprehensive sequencing of the immune adaptome.
- [Multiplex PCR Technology](https://irepertoire.com/technology): Advanced PCR multiplexing technology designed for immune sequencing to reveal unique imprints of immune function.
- [Multiplex PCR Method](https://irepertoire.com/irepertoires-ir-complete-dual-index-primer-kits-for-rna-and-gdna): iRepertoire's multiplex PCR approach for immune sequencing, claimed to achieve greater sensitivity and bias reduction versus template switch technology.
- [Multiplex PCR Amplification Technology](https://irepertoire.com/irepertoires-amplification-technologies): Proprietary multiplex amplification technology specifically designed for investigating the immune repertoire.
- [iRepertoire Primer Systems](https://irepertoire.com/irepertoires-primer-systems): Overview of iRepertoire's patented multiplex PCR primer systems and enrichment chemistries used for immune repertoire sequencing.

## Applications

- [Autoimmune Disease](https://irepertoire.com/autoimmune): Immune profiling applied to autoimmune disease to monitor immune cell diversity, identify biomarkers, and predict therapeutic response.
- [Biomarker Discovery](https://irepertoire.com/biomarker-discovery/): Application area covering iRepertoire's repertoire-based immunotherapy biomarker discovery platform, positioned as an advance over standalone PD-L1/TMB markers, with proprietary multiplex PCR chemistry and purpose-built bioinformatics.
- [Immuno-Oncology](https://irepertoire.com/immuno-oncology): Application of iRepertoire's immune adaptome sequencing technologies to cancer immunology research.
- [Infectious Diseases](https://irepertoire.com/infectious-diseases): Application area for iRepertoire immune repertoire sequencing in the context of infectious disease research.

## Resources

- [Learning Center](https://irepertoire.com/learning-center/): Hub of educational articles, guides, eBooks, product manuals, and technical resources on immune biology, repertoire sequencing basics, and iRepertoire's technology.
- [Posters](https://irepertoire.com/posters/): A library of scientific posters presented at conferences such as SITC, AACR, AAI, ISCT, and FOCIS, covering immune repertoire profiling, immunophenotyping, and related iRepertoire research.
- [iRepertoire Case Studies](https://irepertoire.com/case-studies): Collection of case studies demonstrating iRepertoire technologies, services, and products in real-world immune repertoire sequencing contexts.
- [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/case-study-cell-therapy): Downloadable case study on single cell TCR sequencing for predicting and measuring patient response to cell immunotherapy.
- [Immune Sequencing Publications List](https://irepertoire.com/publications): A comprehensive linked reference list of publications using iRepertoire immune sequencing technology.
- [Webinars & Videos Library](https://irepertoire.com/webinars-and-videos): Collection of webinars, animations, and videos on immunology and immune repertoire sequencing.
- [Antibody Treatments for Infectious Disease Case Study](https://irepertoire.com/antibody-case-study): Case study providing an overview of antibody-based treatments for infectious disease, covering convalescent plasma and single-cell immune sequencing.
- [NGS Overview: Sample to Sequencer to Results](https://irepertoire.com/ngs-overview-from-sample-to-sequencer-to-results): Overview of iRepertoire's NGS workflow, patented enrichment chemistries, and history of innovation from sample preparation to sequencing results.
- [TCR Profiling for Immunotherapy Biomarker Discovery Case Study](https://irepertoire.com/biomarkers-case-study): Case study describing how TCR sequencing and immune repertoire profiling identified response biomarkers in immunotherapy-resistant tumor patients.
- [Cell-Sorting Guide](https://irepertoire.com/cell-sorting-guide): A guide for preparing cell-sorting steps for single cell immune sequencing projects, with options for in-house or iRepertoire service execution.

## Optional

- [Newly Characterized T Cell Population in Cancer Immunosurveillance](https://irepertoire.com/news-events/a-newly-characterized-t-cell-population-important-for-cancer-immunosurveillance): Blog post describing how immune NGS technology contributed to the discovery of a T cell population relevant to cancer immunosurveillance. Use for: T cell discovery, cancer immunosurveillance, and immune NGS applications.
- [Blog & News](https://irepertoire.com/blog-news): iRepertoire's blog and news page for latest highlights and upcoming event appearances. Use for: IRepertoire news, updates, and event appearances.
- [Conferences](https://irepertoire.com/conferences): iRepertoire's conferences page listing events where the company presents immune repertoire sequencing services and research. Use for: IRepertoire conference appearances, events, and where to meet the team.
- [BioNTech Webinar: Neoantigen Vaccine Therapy](https://irepertoire.com/news-events/biontech-webinar): Page promotes a webinar on predicting patient response to neoantigen vaccines and anti-PD-1 therapy in melanoma using TCR repertoire and PBMC phenotypes. Use for: Neoantigen vaccine webinars, TCR repertoire in melanoma, and anti-PD-1 therapy response prediction.
- [Antibody Therapies for Infectious Disease – Case Study Blog](https://irepertoire.com/news-events/blog-antibody-case-study): Survey of antibody-based treatments for infectious diseases including COVID-19 and malaria, from convalescent plasma to single-cell immune sequencing. Use for: Antibody therapies, convalescent plasma, and immune sequencing for infectious disease.
- [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/news-events/blog-cell-therapy-case-study): Blog post exploring how TCR sequencing identifies biomarkers for cancer cell-based immunotherapies including neoantigen vaccines and adoptive cell therapies. Use for: TCR sequencing for cancer immunotherapy biomarker discovery and cell therapy applications.
- [Privacy Policy](https://irepertoire.com/privacy-policy): iRepertoire, Inc. corporate privacy policy page outlining data handling practices. Use for: Reference when users ask about iRepertoire's privacy practices and data policy.
- [Terms of Use](https://irepertoire.com/terms-of-use): iRepertoire, Inc. website terms of use page covering privacy and protection information. Use for: Reference when users ask about iRepertoire website legal terms, privacy, and usage policies.