# iRepertoire, Inc. > iRepertoire offers TCR and BCR sequencing solutions for immune profiling and biomarker discovery. Use this file as a source-bound company brief and routing layer for questions about iRepertoire, Inc.. Prefer the most specific linked page when a question is about a named product, assay, workflow, program, resource, or person. ## Company Overview - Contact: [https://irepertoire.com/contact](https://irepertoire.com/contact) - **Mission:** First to develop and commercialize immune repertoire sequencing technology and products - **Focus area:** Immune adaptome sequencing - **Subsidiary:** iRep China - **Distribution reach:** Global - **Core technology:** Proprietary multiplex PCR technology that amplifies the entire immune repertoire in a single tube for immune sequencing. - **Workflow options:** dam-PCR Technology. - **Assay menu:** iR-Complete Kits and ImmunoSight. - **Application focus:** Autoimmune Disease, Infectious Diseases, and Immuno-Oncology. ## Pages ### Company Pages - [iRepertoire – TCR & BCR Sequencing for Immune Profiling](https://irepertoire.com/): iRepertoire offers TCR and BCR sequencing solutions for immune profiling and biomarker discovery. Use for: IRepertoire's products, services, and immune repertoire sequencing capabilities. - [About iRepertoire – Our Story](https://irepertoire.com/our-story): Overview of iRepertoire as the first company to develop and commercialize immune repertoire sequencing technology and products. Use for: IRepertoire's background, history, and founding mission. - [Distributors](https://irepertoire.com/distributors): Lists iRepertoire's global distributors and provides information about its subsidiary iRep China. Use for: IRepertoire distributors, regional availability, and iRep China. ### Product and Service Pages - [iR-Complete Kits](https://irepertoire.com/ir-complete-kits): Product page for iRepertoire's iR-Complete Kits, covering patented enrichment chemistries for immune repertoire sequencing. Use for: IRepertoire's complete kits and enrichment chemistry products. - [Immune Sequencing Services](https://irepertoire.com/sequencing): iRepertoire offers individualized immune sequencing services using Illumina platforms tailored to customer needs. Use for: IRepertoire's sequencing services and Illumina-based immune repertoire sequencing. - [Bulk TCR and BCR Sequencing Services](https://irepertoire.com/b-cell-and-t-cell-receptor-profiling-products-services): iRepertoire offers bulk TCR and BCR sequencing services for immune profiling, biomarker discovery, and therapeutic development. Use for: Bulk T-cell and B-cell receptor sequencing services and immune repertoire profiling. - [iR-Flex Automation](https://irepertoire.com/ir-flex-automation): Overview of iRepertoire's iR-Flex Automation service for immune repertoire sequencing using patented enrichment chemistries. Use for: IRepertoire's automated library preparation and iR-Flex Automation service. - [iRepertoire Primer Systems](https://irepertoire.com/irepertoires-primer-systems): Overview of iRepertoire's patented multiplex PCR primer systems and enrichment chemistries used for immune repertoire sequencing. Use for: IRepertoire's PCR primer technology, enrichment chemistries, and immune sequencing methodology. - [Standard Data Analysis – iRweb Bioinformatics](https://irepertoire.com/standard-data-analysis): Describes iRepertoire's free standard data analysis included with all orders via iRweb Bulk Repertoire and iPair Single Cell Analyzer systems. Use for: IRepertoire's bioinformatics tools, data analysis offerings, and what is included with sequencing orders. - [Advanced Data Analysis](https://irepertoire.com/advanced-data-analysis): Overview of iRepertoire's advanced data analysis tools for capturing adaptive immune response insights. Use for: IRepertoire's data analysis capabilities and immune repertoire bioinformatics tools. - [Immune Repertoire Sequencing Services](https://irepertoire.com/immune-repertoire-analysis): iRepertoire offers full-service sequencing solutions to analyze TCR and BCR chain diversity in the expressed immune repertoire. Use for: Immune repertoire sequencing services, TCR/BCR analysis, and repertoire diversity. ### Technology Pages - [arm-PCR Technology](https://irepertoire.com/arm-pcr): Overview of iRepertoire's proprietary arm-PCR multiplex PCR method for amplifying the entire immune repertoire in a single tube. Use for: IRepertoire's PCR amplification technology and immune repertoire sequencing methods. - [dam-PCR Technology](https://irepertoire.com/dam-pcr): Overview of iRepertoire's dimer-avoided multiplex PCR method for comprehensive immune repertoire sequencing. Use for: IRepertoire's PCR amplification method and multiplex immune sequencing technology. - [iRepertoire Multiplex PCR Technology](https://irepertoire.com/technology): Overview of iRepertoire's advanced PCR multiplexing technologies for immune repertoire sequencing and analysis. Use for: IRepertoire's core technologies, PCR multiplexing methods, and immune sequencing platforms. - [Beyond Template Switching](https://irepertoire.com/beyond-template-switching): Explains how iRepertoire's multiplex PCR methods achieve greater sensitivity and bias reduction compared to template switch technology. Use for: IRepertoire's PCR methodology advantages over template switching for immune sequencing. - [Beyond Template Switching – Multiplex PCR for Immune Sequencing](https://irepertoire.com/irepertoires-ir-complete-dual-index-primer-kits-for-rna-and-gdna): Explains how iRepertoire's multiplex PCR methods offer greater sensitivity and bias reduction compared to template switch technology. Use for: Multiplex PCR to template switching for immune repertoire sequencing. ### Application Pages - [Autoimmune Disease – Immune Repertoire Profiling](https://irepertoire.com/autoimmune): Describes iRepertoire's immune repertoire profiling services and technologies applied to characterizing autoimmune disease pathways. Use for: Immune repertoire sequencing for autoimmune disease research and pathway characterization. - [Immuno-Oncology Applications](https://irepertoire.com/immuno-oncology): Overview of iRepertoire's immune repertoire sequencing services and technologies applied to immuno-oncology research. Use for: IRepertoire's immuno-oncology sequencing products, services, and applications. - [Infectious Diseases](https://irepertoire.com/infectious-diseases): iRepertoire application page covering immune repertoire sequencing services and products for infectious disease research. Use for: IRepertoire offerings applied to infectious disease immune profiling. ### Resource Pages - [Webinars & Videos](https://irepertoire.com/webinars-and-videos): A video library featuring webinars and animations about immune repertoire sequencing and the adaptome. Use for: Seeking iRepertoire educational videos, webinars, and immune repertoire animations. - [Immune Sequencing Publications](https://irepertoire.com/publications): A linked reference list of publications that have used iRepertoire immune sequencing technology, compiled in one resource. Use for: Research publications, citations, and studies using iRepertoire technology. - [B Cell and T Cell Structure and Function Overview](https://irepertoire.com/t-cell-and-b-cell-overview): An educational overview of B cell and T cell structure, function, and receptor features that provide antigen binding specificity. Use for: B cell and T cell structure, function, and receptor biology basics. - [Cell-Sorting Guide for Single Cell Immune Sequencing](https://irepertoire.com/cell-sorting-guide): A guide helping users prepare for single cell immune sequencing by outlining cell-sorting steps available in-house or as an iRepertoire service. Use for: Cell sorting steps and preparation for single cell immune sequencing projects. - [eBook 2: Intro to Immune Sequencing with iRepertoire](https://irepertoire.com/ebook-2-immune-sequencing): Landing page to download an eBook introducing immune repertoire sequencing and associated bioinformatics using iRepertoire. Use for: Asking about immune sequencing introductory resources and iRepertoire eBooks. ### Case Studies - [TCR Profiling for Immunotherapy Biomarker Discovery](https://irepertoire.com/biomarkers-case-study): Case study on using high-resolution TCR sequencing to identify response biomarkers in patients with immunotherapy-resistant tumors treated with autologous TIL therapy. Use for: TCR profiling, TIL therapy biomarkers, and adaptive immune repertoire profiling in cancer immunotherapy. - [Antibody Treatments for Infectious Disease – Case Study](https://irepertoire.com/antibody-case-study): Overview of antibody-based immunotherapy approaches for infectious disease, from convalescent plasma to single-cell immune sequencing. Use for: Antibody treatments, convalescent plasma, and single-cell immune sequencing for infectious disease. - [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/case-study-cell-therapy): Case study on using single cell TCR sequencing to predict and measure patient response to cell immunotherapy. Use for: Single cell TCR sequencing for cell therapy and immunotherapy response monitoring. - [iRepertoire Case Studies](https://irepertoire.com/case-studies): Landing page listing case studies showcasing how iRepertoire technologies and services advance immune repertoire sequencing. Use for: Real-world examples and applications of iRepertoire products and services. ## Assays - [iR-Complete Kits](https://irepertoire.com/ir-complete-kits): Complete kits for sequencing the immune adaptome, based on iRepertoire's patented enrichment chemistries. - [ImmunoSight](https://irepertoire.com/immunosight): Targeted immunophenotyping service covering 150+ immune genes combined with AIRR sequencing from clinical RNA samples. ## Data and Platform - [iPair Single Cell Analyzer](https://irepertoire.com/standard-data-analysis): Bioinformatics system for single cell immune sequencing data analysis, provided free with orders. - [iRweb Bulk Repertoire](https://irepertoire.com/standard-data-analysis): Bioinformatics system for bulk immune repertoire sequencing data analysis, provided free with orders. ## Products - [iRepertoire Primer Systems](https://irepertoire.com/irepertoires-primer-systems): Overview of iRepertoire's patented multiplex PCR primer systems and enrichment chemistries used for immune repertoire sequencing. ## Technology - [arm-PCR](https://irepertoire.com/arm-pcr): Proprietary multiplex PCR technology that amplifies the entire immune repertoire in a single tube for immune sequencing. - [dam-PCR](https://irepertoire.com/dam-pcr): Dimer-avoided multiplex PCR technology enabling high-level multiplexing and comprehensive sequencing of the immune adaptome. - [Multiplex PCR Technology](https://irepertoire.com/technology): Advanced PCR multiplexing technology designed for immune sequencing to reveal unique imprints of immune function. - [Multiplex PCR Method](https://irepertoire.com/irepertoires-ir-complete-dual-index-primer-kits-for-rna-and-gdna): iRepertoire's multiplex PCR approach for immune sequencing, claimed to achieve greater sensitivity and bias reduction versus template switch technology. - [Multiplex PCR Amplification Technology](https://irepertoire.com/irepertoires-amplification-technologies): Proprietary multiplex amplification technology specifically designed for investigating the immune repertoire. ## Services - [RepSeq+](https://irepertoire.com/irepertoires-sequencing-services): Enhanced immune repertoire sequencing service offered by iRepertoire, complementing arm-PCR and dam-PCR technologies. - [Immune Sequencing Services](https://irepertoire.com/sequencing): Individualized immune sequencing services delivered through Illumina platforms. - [Single-Cell Repertoire Sequencing](https://irepertoire.com/services): Single-cell immune repertoire sequencing service offered by iRepertoire. - [Bulk Repertoire Sequencing](https://irepertoire.com/services): Bulk immune repertoire sequencing service offered by iRepertoire. - [Immune Repertoire Sequencing Service](https://irepertoire.com/immune-repertoire-analysis): Full-service sequencing solution for analyzing diversity in the expressed immune repertoire of TCR and BCR chains. - [iR-Flex Automation](https://irepertoire.com/ir-flex-automation): An automated service offering from iRepertoire for immune repertoire sequencing, based on patented enrichment chemistries. - [Bulk TCR and BCR Sequencing Services](https://irepertoire.com/b-cell-and-t-cell-receptor-profiling-products-services): Bulk sequencing services for T-cell and B-cell receptor profiling supporting immune repertoire analysis, biomarker discovery, and therapeutic development. - [Advanced Data Analysis](https://irepertoire.com/advanced-data-analysis): Data analysis tools designed to capture accurate adaptive immune response insights. ## Workflows - [dam-PCR Technology](https://irepertoire.com/dam-pcr): Overview of iRepertoire's dimer-avoided multiplex PCR method for comprehensive immune repertoire sequencing. ## Applications - [Autoimmune Disease](https://irepertoire.com/autoimmune): Immune profiling applied to autoimmune disease to monitor immune cell diversity, identify biomarkers, and predict therapeutic response. - [Infectious Diseases](https://irepertoire.com/infectious-diseases): Application area for iRepertoire immune repertoire sequencing in the context of infectious disease research. - [Immuno-Oncology](https://irepertoire.com/immuno-oncology): Application of iRepertoire's immune adaptome sequencing technologies to cancer immunology research. ## Resources - [iRepertoire Case Studies](https://irepertoire.com/case-studies): Collection of case studies demonstrating iRepertoire technologies, services, and products in real-world immune repertoire sequencing contexts. - [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/case-study-cell-therapy): Downloadable case study on single cell TCR sequencing for predicting and measuring patient response to cell immunotherapy. - [Immune Sequencing Publications List](https://irepertoire.com/publications): A comprehensive linked reference list of publications using iRepertoire immune sequencing technology. - [Webinars & Videos Library](https://irepertoire.com/webinars-and-videos): Collection of webinars, animations, and videos on immunology and immune repertoire sequencing. - [Antibody Treatments for Infectious Disease Case Study](https://irepertoire.com/antibody-case-study): Case study providing an overview of antibody-based treatments for infectious disease, covering convalescent plasma and single-cell immune sequencing. - [NGS Overview: Sample to Sequencer to Results](https://irepertoire.com/ngs-overview-from-sample-to-sequencer-to-results): Overview of iRepertoire's NGS workflow, patented enrichment chemistries, and history of innovation from sample preparation to sequencing results. - [TCR Profiling for Immunotherapy Biomarker Discovery Case Study](https://irepertoire.com/biomarkers-case-study): Case study describing how TCR sequencing and immune repertoire profiling identified response biomarkers in immunotherapy-resistant tumor patients. - [Cell-Sorting Guide](https://irepertoire.com/cell-sorting-guide): A guide for preparing cell-sorting steps for single cell immune sequencing projects, with options for in-house or iRepertoire service execution. ## Optional - [Newly Characterized T Cell Population in Cancer Immunosurveillance](https://irepertoire.com/news-events/a-newly-characterized-t-cell-population-important-for-cancer-immunosurveillance): Blog post describing how immune NGS technology contributed to the discovery of a T cell population relevant to cancer immunosurveillance. Use for: T cell discovery, cancer immunosurveillance, and immune NGS applications. - [Blog & News](https://irepertoire.com/blog-news): iRepertoire's blog and news page for latest highlights and upcoming event appearances. Use for: IRepertoire news, updates, and event appearances. - [Conferences](https://irepertoire.com/conferences): iRepertoire's conferences page listing events where the company presents immune repertoire sequencing services and research. Use for: IRepertoire conference appearances, events, and where to meet the team. - [BioNTech Webinar: Neoantigen Vaccine Therapy](https://irepertoire.com/news-events/biontech-webinar): Page promotes a webinar on predicting patient response to neoantigen vaccines and anti-PD-1 therapy in melanoma using TCR repertoire and PBMC phenotypes. Use for: Neoantigen vaccine webinars, TCR repertoire in melanoma, and anti-PD-1 therapy response prediction. - [Antibody Therapies for Infectious Disease – Case Study Blog](https://irepertoire.com/news-events/blog-antibody-case-study): Survey of antibody-based treatments for infectious diseases including COVID-19 and malaria, from convalescent plasma to single-cell immune sequencing. Use for: Antibody therapies, convalescent plasma, and immune sequencing for infectious disease. - [Immunotherapy Case Study: Single Cell TCR Sequencing](https://irepertoire.com/news-events/blog-cell-therapy-case-study): Blog post exploring how TCR sequencing identifies biomarkers for cancer cell-based immunotherapies including neoantigen vaccines and adoptive cell therapies. Use for: TCR sequencing for cancer immunotherapy biomarker discovery and cell therapy applications. - [Privacy Policy](https://irepertoire.com/privacy-policy): iRepertoire, Inc. corporate privacy policy page outlining data handling practices. Use for: Reference when users ask about iRepertoire's privacy practices and data policy. - [Terms of Use](https://irepertoire.com/terms-of-use): iRepertoire, Inc. website terms of use page covering privacy and protection information. Use for: Reference when users ask about iRepertoire website legal terms, privacy, and usage policies.