Understanding what dictates patient response to immunotherapies with single cell immune sequencing
Cancer cell-based immunotherapies, including neoantigen vaccines and adoptive cell therapies, have attracted great attention recently for their therapeutic effects. However, patient response to cell therapies can vary widely. Predicting patient response has become a critical area for research to more effectively personalize treatment for optimal clinical outcomes and minimized costs.
Single cell immune sequencing, particularly TCR sequencing, has shown promising results in predicting patient response to different treatments. Read this case study on two recent applications of immune sequencing and how it has been used to shed light on the key role of the immune repertoire in immunotherapy response.