Quantitative gDNA TCR/BCR Sequencing with RepSeq IQ™
Quantitative gDNA TCR/BCR Sequencing with RepSeq IQ™
Visit us at our booth to connect with our team and explore the latest advancements in immune repertoire sequencing, data analysis, and biomarker discovery.
Discover our comprehensive single-cell V(D)J and bulk immune repertoire sequencing services, and see how Intellimune™ transforms complex AIRR data into actionable insights. Learn about the latest innovations at iRepertoire and how advanced immune profiling is accelerating research across immuno-oncology, infectious diseases, autoimmune disorders, and cell therapy development.
A patient’s unique profile of B and T cells determines their ability to neutralize cancer cells and is predictive of their response to immunotherapies. But typical immune cell sequencing approaches do not preserve crucial information related to the cognate pairing of receptor chains and fail to capture critically important rare cell types.
iPair™ is the first commercialized technology for capturing physically paired, full-length V(D)J sequences from FACS-isolated single T and B cells in the same reaction well, with over 90% amplification success and over 80% pairing success.
Single cell sequencing supports CAR-T cell therapy development by identifying neoantigen-reactive clones, tracking cellular clonality, and measuring the persistence and expansion of infused cell products. Bundle iPair with Immunosight to add gene expression data across 150+ immune genes for a complete view of cell function alongside receptor sequence.
Immune repertoire analysis can reveal biomarkers for diagnosis, prognosis, and treatment monitoring, but realizing that potential means overcoming inconsistent sample prep, technical bias, and the sheer diversity of the adaptome. Standard sequencing approaches often can’t distinguish true biological signal from noise or compare results reliably across patients, samples, and timepoints.
RepSeq+ delivers comprehensive, quantitative analysis of the adaptome from a wide range of sample types, including DNA, RNA, FFPE, whole blood, sorted cells, bone marrow, and tissue. Our multiplex PCR technology simultaneously amplifies any combination of all 7 chains of the adaptive immune system in a single reaction, enhanced with UMI-based error correction, unlocking over 200 immune repertoire metrics as potential biomarkers.
RepSeq+ data supports treatment monitoring and biomarker discovery across immuno-oncology, autoimmune disease, and infectious disease
Adaptive immune receptor repertoire sequencing generates rich, expansive datasets, but capturing actionable biological and clinical insight takes more than sequence mapping and basic diversity metrics. Standard analysis pipelines often leave rare clonotypes, clonal evolution, and antigen-driven selection hidden in the data.
Intellimune™ transforms raw AIRR data into clear, reproducible, decision-ready insights. Built by immunology and computational experts, Intellimune combines proven bioinformatics workflows with advanced visualization and expert interpretation, letting you detect rare, disease-relevant clonotypes, compare repertoires across samples and timepoints, and translate complex data into biological conclusions you can act on.
Intellimune scales with your study. Every project includes Intellimune Standard for foundational repertoire characterization, with Plus and Pro tiers adding deeper diversity metrics, somatic hypermutation analysis, and cohort-level insights. For hypothesis-driven or translational questions, Intellimune Discovery offers fully customized, expert-guided analysis tailored to your program, from biomarker discovery to vaccine development to cell therapy monitoring.
iRepertoire is a leader in immune repertoire sequencing and data analysis. Consult with our team of scientists to discover how RepSeq, iPair, and Intellimune can accelerate your research, from sequencing through biomarker discovery.
