March 11, 2020 |

Publications

Publications

Coelho, C. H. et al. A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nat Commun 12, 1750 (2021). https://doi.org/10.1038/s41467-021-21955-1

Poran, A. et al. Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1. CR Med 1, (2020). https://doi.org/10.1016/j.xcrm.2020.100141

Coelho, C. H. et al. Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing. JCI Insight (2020). https://doi.org/10.1172/jci.insight.143471

Quayle, S. N. et al. CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies. Clinical Cancer Research 26, 1953–1964 (2020). https://doi.org/10.1158/1078-0432.CCR-19-3354

Soloff, A. C. et al. HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions. Frontiers in Immunology 11, (2020). https://doi.org/10.3389/fimmu.2020.02027

Niu, X. et al. Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients. Front. Immunol. 11, (2020). https://doi.org/10.3389/fimmu.2020.582010

Prokop, J. W. et al. Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19. Physiological Genomics 52, 255–268 (2020). https://doi.org/10.1152/physiolgenomics.00045.2020

Chen, H. et al. Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis. Cell Mol Immunol 16, 250–259 (2019). https://doi.org/10.1038/cmi.2017.157

Konishi, H. et al. Capturing the differences between humoral immunity in the normal and tumor environments from repertoire-seq of B-cell receptors using supervised machine learning. BMC Bioinformatics 20, 267 (2019). https://doi.org/10.1186/s12859-019-2853-y

Huang, W. et al. Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients. JCI Insight 3, (2018). https://doi.org/10.1172/jci.insight.122525.

Hou, X. et al. Identification of paired heavy and light chains from single B-cells from immunized Malian adults with rapid functional confirmation using iPair-BCRTM, NGS, and iScreenTM. J. Immunol. 200, 174.36 (2018). https://www.jimmunol.org/content/200/1_Supplement/174.36

Wu, J. et al. Expanded TCRβ CDR3 clonotypes distinguish Crohn’s disease and ulcerative colitis patients. Mucosal Immunol 11, 1487–1495 (2018). https://doi.org/10.1038/s41385-018-0046-z

Cheng, C. et al. Next generation sequencing reveals changes of the γδ T cell receptor repertoires in patients with pulmonary tuberculosis. Sci Rep 8, 1–13 (2018). https://doi.org/10.1038/s41598-018-22061-x

Hunter, S. et al. Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations. Journal of Hepatology 69, 654–665 (2018). https://doi.org/10.1016/j.jhep.2018.05.007

Jiang, Q. et al. Patient-shared TCRβ-CDR3 clonotypes correlate with favorable prognosis in chronic hepatitis B. European Journal of Immunology 48, 1539–1549 (2018). https://doi.org/10.1002/eji.201747327

Dickinson, G. S. et al. IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity. The Journal of Immunology 201, 1229–1240 (2018). https://doi.org/10.4049/jimmunol.1800162

Jiang, Q. et al. Analysis of T cell receptor repertoire in monozygotic twins concordant and discordant for chronic hepatitis B infection. Biochemical and Biophysical Research Communications 497, 153–159 (2018). https://doi.org/10.1016/j.bbrc.2018.02.043

Textor, J. et al. Deep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones during an Immune Response. The Journal of Immunology 201, 350–358 (2018). https://doi.org/10.4049/jimmunol.1800091

Fähnrich, A. et al. CD154 Costimulation Shifts the Local T-Cell Receptor Repertoire Not Only During Thymic Selection but Also During Peripheral T-Dependent Humoral Immune Responses. Front. Immunol. 9, (2018). https://dx.doi.org/10.3389%2Ffimmu.2018.01019

Tedesco, D. et al. Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology 154, 2178–2193 (2018). https://doi.org/10.1053/j.gastro.2018.02.019

Davey, M. S. et al. The human Vδ2 + T-cell compartment comprises distinct innate-like Vγ9 + and adaptive Vγ9 – subsets. Nat Commun 9, 1–14 (2018). https://doi.org/10.1038/s41467-018-04076-0

Shukla, G. S. et al. Immunization with tumor neoantigens displayed on T7 phage nanoparticles elicits plasma antibody and vaccine-draining lymph node B cell responses. Journal of Immunological Methods 460, 51–62 (2018). https://doi.org/10.1016/j.jim.2018.06.009

Fahl, S. P. et al. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Proc Natl Acad Sci USA 115, 1889 (2018). https://doi.org/10.1073/pnas.1718328115

Davey, M. S. et al. Recasting Human Vδ1 Lymphocytes in an Adaptive Role. Trends in Immunology 39, 446–459 (2018). https://doi.org/10.1016/j.it.2018.03.003

Zhang, C. et al. Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire. Front. Immunol. 9, (2018). https://doi.org/10.3389/fimmu.2018.00908

McCaw, T. R. et al. The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth. bioRxiv 294124 (2018). https://doi.org/10.1101/294124

Spence, A. et al. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. PNAS 115, 5265–5270 (2018). https://doi.org/10.1073/pnas.1715590115

Mitchell, A. M. et al. CD4+ T cell receptor repertoire in sarcoidosis patients. The Journal of Immunology 198, 55.36-55.36 (2017). https://www.jimmunol.org/content/198/1_Supplement/55.36

Okano, T. et al. Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy. Clinical Immunology 183, 112–120 (2017). https://doi.org/10.1016/j.clim.2017.08.003

Davey, M. S. et al. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nat Commun 8, 1–15 (2017). https://doi.org/10.1038/ncomms14760

Barisa, M. et al. E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner. Sci Rep 7, 1–12 (2017). https://doi.org/10.1038/s41598-017-02886-8

Mitchell, A. M. et al. Shared αβ TCR Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome. The Journal of Immunology 199, 2279–2290 (2017). https://doi.org/10.4049/jimmunol.1700570

Probst, P. et al. Sarcoma eradication by doxorubicin and targeted TNF relies upon CD8+ T cell recognition of a retroviral antigen. Cancer Res canres.2946.2016 (2017). https://cancerres.aacrjournals.org/content/early/2017/05/06/0008-5472.CAN-16-2946

Chen, H. et al. Characterization of the diversity of T cell receptor γδ complementary determinant region 3 in human peripheral blood by Immune Repertoire Sequencing. Journal of Immunological Methods 443, 9–17 (2017). https://doi.org/10.1016/j.jim.2017.01.009

Katoh, H. et al. Immunogenetic Profiling for Gastric Cancers Identifies Sulfated Glycosaminoglycans as Major and Functional B Cell Antigens in Human Malignancies. Cell Reports 20, 1073–1087 (2017). https://doi.org/10.1016/j.celrep.2017.07.016

Wong, H.S. et al. V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients. J Biomed Sci 24, 43 (2017). https://doi.org/10.1186/s12929-017-0349-5

Ritvo, P.-G. et al. High-resolution repertoire analysis of Tfr and Tfh cells reveals unexpectedly high diversities indicating a bystander activation of follicular T cells. bioRxiv 231977 (2017). https://doi.org/10.1101/231977

Hou, D. et al. Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients. Sci Rep 6, 1–11 (2016). https://doi.org/10.1038/srep33843

Al-Hussaini, M. et al. Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform. Blood 127, 122–131 (2016). https://doi.org/10.1182/blood-2014-05-575704

Lee, Y. N. et al. Characterization of T and B cell repertoire diversity in patients with RAG deficiency. Science Immunology 1, (2016). https://immunology.sciencemag.org/content/1/6/eaah6109

Sims, J. S. et al. Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire. PNAS 113, E3529–E3537 (2016). https://doi.org/10.1073/pnas.1601012113

Riser, et al. A Comprehensive Analysis of Relapse in Multiple Sclerosis. CMSC Actrims 2015. https://cmsc.confex.com/cmsc/2015/webprogram/Paper3660.html

Byrne-Steele, M. et al. iRock 2.0 and the iR-Processor: an automated immune repertoire library preparation platform for NGS (TECH2P.919). The Journal of Immunology 194, 206.29-206.29 (2015). https://www.jimmunol.org/content/194/1_Supplement/206.29

Yang, Y. et al. Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires. eLife 4, e09083 (2015). https://doi.org/10.7554/eLife.09083

Zhao, T. et al. Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell 17, 353–359 (2015). https://doi.org/10.1016/j.stem.2015.07.021

Byrne-Steele, M. et al. Automation of immune repertoire amplification on the iC-Processor (TECH1P.851). The Journal of Immunology 192, 69.19-69.19 (2014). https://www.jimmunol.org/content/192/1_Supplement/69.19

Alleyne, J. et al. Biomarker: long term study of breast cancer specific CDR3s in peripheral blood (TUM2P.894). J. Immunol. 192, 71.18 (2014). https://www.jimmunol.org/content/192/1_Supplement/71.18

O’Connell, A. E. et al. Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients with Wiskott–Aldrich Syndrome. Front. Immunol. 5, (2014). https://doi.org/10.3389/fimmu.2014.00340

Lee, Y. N. et al. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. Journal of Allergy and Clinical Immunology 133, 1099-1108.e12 (2014). https://doi.org/10.1016/j.jaci.2013.10.007

Sims, J. et al. IT-32 Divergence of Intratumoral and Systemic T Cell Repertoires Reflects Local Monocyte Profiles During Glioma Progression. Neuro Oncol 16, v116–v117 (2014). https://doi.org/10.1093/neuonc/nou258.30

Sims, J. et al. TCR repertoire divergence reflects micro-environmental immune phenotypes in glioma. J Immunother Cancer 2, O19 (2014). http://dx.doi.org/10.1186/2051-1426-2-S3-O19

Wang, C. et al. Breast cancer diagnosis by high throughput sequencing of T cell receptors from peripheral blood samples (TUM2P.905). The Journal of Immunology 192, 71.29-71.29 (2014). https://www.jimmunol.org/content/192/1_Supplement/71.29

Sims, J. S. et al. Tumor-associated T cell receptor repertoires in low- and high-grade gliomas. J Immunother Cancer 1, P143 (2013). http://dx.doi.org/10.1186/2051-1426-1-S1-P143

Han, J. et al. R10K update: NGS of immune repertoire for biomarker discoveries (P3241). J. Immunol. 190, 192.6 (2013). https://www.jimmunol.org/content/190/1_Supplement/192.6

Peaudecerf, L. et al. Thymocytes may persist and differentiate without any input from bone marrow progenitors. J Exp Med 209, 1401–1408 (2012). https://doi.org/10.1084/jem.20120845

Han, J. et al. Identification and temporal monitoring of breast cancer-associated T cell receptors with high throughput sequencing (46.23). The Journal of Immunology 188, 46.23-46.23 (2012). https://www.jimmunol.org/content/188/1_Supplement/46.23

Wang, C. et al. Evaluation of three next generation sequencing platforms for immune repertoire sequencing (58.10). The Journal of Immunology 188, 58.10-58.10 (2012). https://www.jimmunol.org/content/188/1_Supplement/58.10

Han, J. et al. R10K: an international collaborative project for biomarker discovery (58.7). The Journal of Immunology 188, 58.7-58.7 (2012). https://www.jimmunol.org/content/188/1_Supplement/58.7

Byrne-Steele, M. et al. Development of an alternative method for the identification and production of antigen-specific monoclonal antibodies (65.16). The Journal of Immunology 186, 65.16-65.16 (2011). https://www.jimmunol.org/content/186/1_Supplement/65.16

Han, J. et al. Profiling the pattern of human immunoglobulin SHM and CSR in B memory cells via high-throughput sequencing (62.11). The Journal of Immunology 186, 62.11-62.11 (2011). https://www.jimmunol.org/content/186/1_Supplement/62.11

Wang, C. et al. Immune repertoire high-throughput sequence analysis (IRAS) web service (65.20). J. Immunol. 186, 65.20 (2011). https://www.jimmunol.org/content/186/1_Supplement/65.20

Wang, C. et al. High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. PNAS 107, 1518–1523 (2010). https://doi.org/10.1073/pnas.0913939107