Quantitative gDNA TCR/BCR Sequencing with RepSeq IQ™

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iRepertoire, Inc.

Case Studies

Case Study: Predicting and measuring patient response to cell therapy with single cell TCR sequencing

Case Study: Immune Repertoire Sequencing for Pre- and Post-Treatment Monitoring in Cancer

Case Study: The evolution of antibody-based treatments for infectious disease

Case study: Mitigating AIRRseq Challenges in FFPE Tissue Samples with the RepSeq+ Immune Repertoire Intelligence Platform​

Case study: Immune Repertoire Profiling to Understand the Autoimmune Disease State

Therapeutic Case Study

Case study: Immune Repertoire Profiling to Assess Therapeutic Response in Autoimmune Disease

A thumbnail of Biomarker case study

Case study: Immune Repertoire Profiling for Immunotherapy Biomarker Discovery

Case Studies

Analyzing the immune repertoire for cancer diagnostic/prognostic purposes

Read this case study for an overview of how sequencing has led to the identification of clinical indicators of various disease states, uniquely applied to oncology. Discover how:

  • Clonal propagation and repertoire diversity correlate with diagnosis/prognosis.
  • TCR and BCR expression patterns correlate with treatment efficacy.
  • Novel immune sequencing tools enable tracking of all seven chains throughout immunotherapy studies.
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Understanding what dictates patient response to immunotherapies with single-cell immune sequencing

Read this case study on two recent applications of immune sequencing and how it has been used to shed light on the key role of the immune repertoire in immunotherapy response. Learn how:

  • TCR diversity can be used as a predictor for immunotherapy treatment success.
  • Single-cell TCR sequencing can identify antigen-specific responses.
  • Detailed immune repertoires allow for personalized treatment selection rather than relying on population-level responses.
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Exploring the evolution of antibody-based treatments: From convalescent plasma to single-cell immune sequencing

Read this case study to learn about the historical and modern progress of antibody-based therapies for infectious diseases, ranging from the Spanish Flu, Ebola, and now malaria and COVID-19. Explore how:

  • Antibodies produced in the immune systems of survivors are the most potent protectant against waves of infectious disease.
  • Single-cell sequencing can transform how we fight infectious diseases.
  • Technological advancements have reduced antibody discovery from months to days.
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Autoimmune case study

Gaining key insights into the autoimmune disease state

Autoimmune diseases are the third most common cause of chronic illness in the US, and their prevalence is increasing globally. Yet, little is understood about the mechanisms that lead to autoimmunity. Read this case study to learn how immune repertoire profiling:

  • Enables the discovery of new autoimmunity biomarkers.
  • Sheds light on the underlying mechanisms contributing to autoimmune diseases like Rheumatoid Arthritis (RA) and SLE.
  • Provides diagnostic predictor variables for RA.
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Thumbnail image of a case study cover page titled ‘Immune Repertoire Profiling to Assess Therapeutic Response in Autoimmune Disease,’ featuring stylized scientific graphics and branding from iRepertoire, indicating immune repertoire analysis in autoimmune therapy evaluation

Characterizing and predicting autoimmune disease therapeutic response

Autoimmune diseases are complex, multi-factorial, and dynamic. With immune profiling, it is possible to precisely monitor changes in immune cell diversity over time and post-therapy to identify biomarkers, inform clinical study design, and predict therapeutic response. Read this case study to discover how immune repertoire profiling:

  • Enables quantitative and highly reproducible analysis of the full diversity of BCR and TCR repertoires.
  • Provides information about RA and SLE patient response to immunosuppressant therapy.
  • Contributes insights that may enable personalized medicine interventions for autoimmune disease management.
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FFPE Case Study

Obtaining reliable seven-chain AIRRseq from challenging FFPE samples

Formalin-fixed paraffin-embedded (FFPE) tissues are invaluable for clinical research but pose significant technical challenges for TCR and BCR sequencing. In this case study, you will learn how:

  • Implementing FFPE sample collection and preservation best practices maximizes nucleic acid integrity.
  • Our optimized workflow overcomes FFPE barriers to deliver reliable and quantitative immune repertoire profiling.
  • Comprehensive analytical solutions allow both mapping and tracking of clonal frequencies over treatment.
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