Develop effective infectious disease therapeutics with our decision-ready immune biomarker platform
The adaptive immune system records the body’s responses to infection, providing insight into protective immunity, vaccine efficacy, and disease severity. But infectious disease programs often struggle to measure rare antigen-specific clones, resolve BCR isotypes, or track multi-chain responses with enough sensitivity or consistency to guide clinical decisions.
We provide comprehensive, unbiased seven-chain bulk sequencing, single-cell receptor pairing, and data analysis services that deliver the resolution and accuracy required for confident biomarker identification and therapeutic development. Deep, quantitative TCR and BCR profiling of immunized individuals can provide mechanistic context for protective immunity, identify rare antibody sequences with high affinity to specific antigens, and enable rapid modification and production of protective monoclonal antibodies and vaccines.
Leverage pathogen-specific immune responses to improve therapeutic design
Decoding Adaptive Immunity in Infection
Understanding adaptive immune responses to bacterial, viral, and fungal infections remains a major barrier in translational research.
Explore this case study to see how iRepertoire’s adaptive immune receptor repertoire profiling:
- Delivers unprecedented resolution into pathogen-specific T and B cell responses
- Provides physically paired V(D)J receptor sequences directly from primary cells to accelerate therapeutic antibody discovery
- Generates clinically meaningful insights that guide vaccine design and enable more predictive infectious-disease biomarkers
See how our platform transforms immune data into infectious disease insights
Advance new vaccine technologies and develop high-specificity neutralizing antibodies with iRepertoire's BCR and TCR sequencing services
Both single cell and immune repertoire sequencing can be used to evaluate the immune response to new vaccines and to identify those very important and infrequent B and T cells responsible for neutralizing pathogens.
Take a look at this webinar and publication by Dr. Camila Coehlo demonstrating how iPair was used to identify low frequency antigenspecific B cells in response to a novel Pfs230 transmission blocking vaccine.
WEBINAR
B cell sequencing as a tool to improve malaria vaccinology webinar
PUBLICATION
Human monoclonal antibody blocks malaria transmission
PUBLICATION
Expansion of the T cell repertoire can protect against malaria
Identify patient-specific immune responses to infection using iRepertoire's quantitative and reproducible 7-chain sequencing technology.
Sequencing data has provided granular information about individual T and B cell populations of patients with COVID-19.
This unprecedented detail can be leveraged to characterize host response to other infectious diseases and advance new therapies and treatment strategies.
PUBLICATION
Abnormal adaptive immune system in COVID-19 survivors
PUBLICATION
B and T cell responses in patients after COVID-19 infection
BLOG
Immune system map in response to COVID-19
Capture rare neutralizing antibodies with single cell immune sequencing for biomarker discovery
Single cell and bulk repertoire sequencing can be used to identify rare cell populations and infection signatures as biomarkers for neutralizing antibody and drug development.
Bulk repertoire analysis can identify infection signatures with prognostic utility, and single cell sequencing can be used to capture rare effector B cells for therapeutic antibody development. For methods that utilize hybridomas to screen for reactive antibodies, iRepertoire’s hybridoma sequencing services provide a high-resolution assessment of full length paired receptors at a lower cost than traditional approaches. By incorporating sequencing during the production stage for all reactive hybridomas, redundancy can be identified prior to costly functional activity experiments, while digitizing valuable hybridoma sequences can provide peace of mind.
WEBINAR
COVID-19 Research Symposium
PUBLICATION
Harnessing T cell repertoire to prevent HIV replication
BROCHURE
Hybridoma sequencing
Uncovering Protective T Cell Responses in Malaria
Explore how advanced immune repertoire profiling reveals the role of unconventional T cells in driving protective immunity to malaria. This webinar highlights how deep TCR sequencing can map clonal expansion and antigen-specific responses, uncovering immune signatures that inform vaccine development and enable the discovery of clinically relevant biomarkers.
WEBINAR
Unconventional T cell Immunity in Malaria
WEBINAR
B cell sequencing as a tool to improve malaria vaccinology webinar
Explore our services
Bulk immune repertoire profiling
Discover RepSeq+, our sensitive, quantitative, and high-throughput assay that combines multiplex PCR with NGS to analyze any combination of all seven chains of the adaptive immune system in a single reaction.
Single cell V(D)J profiling
Explore iPair, the first commercialized technology for capturing physically paired full-length V(D)J sequences in TCRs or BCRs from FACS isolated single cells in the same reaction well.
Data Analysis
Leverage our built-for-purpose, advanced AIRR analysis tools that translate raw sequence data into actionable insights.
Additional resources
Ready to get started?
iRepertoire serves as a leader in the field of immune repertoire profiling. We invite you to consult with our team of scientists to discover how our services can accelerate your analysis of immune cell function and diversity.