Technology

Inspiring clinically-actionable discoveries in immune biology

Sequence the full variable region of all 7 chains for single cells or bulk repertoires

An immune repertoire is the sum of functionally diverse T and B cells in a body at any given moment. Sampling
the immune repertoire provides both a snapshot and a historical record of immune function, enabling an advanced understanding of disease and treatment response.

Over the last 10 years, iRepertoire has developed the gold standard technologies for immune repertoire sequencing and continues to innovate new solutions for profiling the adaptome. Our core technologies provide the ability to amplify all of the expressed V(D)Js in B or T cells, and we offer the only technology that can measure all 7 immune chains in a single reaction. iRepertoire is committed to the creation of cutting-edge technology that adapts to the
ever-changing immune sequencing landscape.

arm-PCR

Amplicon Rescue Multiplex PCR

arm-PCR inclusively amplifies all of the expressed V(D)Js in B or T cells for cost-efficient insights into the expressed immune repertoire. arm-PCR is ideal for capturing rare cell types, tetramer analysis, and single cell applications even for low volume and difficult to handle sample types.

Learn More See Case Study

dam-PCR

Dimer avoided multiplex PCR

dam-PCR enables highly quantitative amplification of any combination of TCR and BCR chains (alpha, beta, delta, gamma, IgH, and kappa/lambda) in a single reaction. dam-PCR is ideal for isotype and clonotype frequency analysis, hyper-mutation status, and FFPE-damaged samples.

Learn More See Case Study

Streamlined single cell immune sequencing for paired chain and phenotypic analysis

Single cell immune sequencing preserves information about the cognate pairing of BCR and TCR chains. Paired TCR and BCR chains are shown in the wells of a stylized iPair plate.
V(D)J RNA amplified and sequenced

Our iPair single cell immune sequencing technology is the first commercially available service specifically designed for capturing physically paired variable regions in T cells and B cells. Our iPair+ single cell immune phenotyping technology allows for co-expression analysis of over 100 phenotypic genes.

iPair Applications

  • Paired chain analysis
  • CAR-T development
  • Lymphocyte tracking
  • Antibody reverse engineering
  • Rare cell analysis
Learn More See Case Study

Enabling flexible inputs, more insights, and efficiency

iRepertoire immune sequencing | Competitor analysis

Investor deck image
Coverage
iRepertoire
Technologyarm-PCR and dam-PCR
BULK SEQUENCING AVAILABLE?Yes
SINGLE CELL SEQUENCING AVAILABLE?Yes
HUMAN CDRCDR1, CDR2, & CDR3
MOUSE CDRCDR1, CDR2
IGHHuman & Mouse
IGLHuman & Mouse
IGKHuman & Mouse
TCRBHuman & Mouse
TCRAHuman & Mouse
TCRDHuman & Mouse
TCRGHuman & Mouse
BCR ISOTYPEYes
UMI AVAILABLE?Yes
INPUT (RNA/DNA)RNA or DNA
PRICE$
Competitor A
Technologymultiplex-PCR
BULK SEQUENCING AVAILABLE?Yes
SINGLE CELL SEQUENCING AVAILABLE?No
HUMAN CDRCDR3 only
MOUSE CDRCDR3 only
IGHHuman & Mouse
IGLNot Covered
IGKNot Covered
TCRBHuman & Mouse
TCRAHuman
TCRDHuman
TCRGHuman
BCR ISOTYPENo
UMI AVAILABLE?No
INPUT (RNA/DNA)DNA
PRICE$$
Competitor B
Technologytemplate switch
BULK SEQUENCING AVAILABLE?Yes (10K cell max)
SINGLE CELL SEQUENCING AVAILABLE?Yes
HUMAN CDRCDR1, CDR2, & CDR3
MOUSE CDRCDR1, CDR2, & CDR3
IGHHuman & Mouse
IGLHuman & Mouse
IGKHuman & Mouse
TCRBHuman & Mouse
TCRAHuman & Mouse
TCRDHuman & Mouse
TCRGHuman & Mouse
BCR ISOTYPEYes
UMI AVAILABLE?Yes
INPUT (RNA/DNA)RNA
PRICE$$$

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