High-resolution immune repertoire insights

Single cell sequencing

for CAR-T cell therapy development & immunotherapy trials

A patient’s unique profile of B and T cells determines their ability to neutralize cancer cells and is predictive of their response to immunotherapies. But typical immune cell sequencing approaches do not preserve crucial information related to the cognate pairing of receptor chains and fail to capture critically important rare cell types.

With our single cell sequencing service, iPair™, you can specifically capture physically paired variable regions in individual T cells and B cells for improved sensitivity, characterization, and resolution. Go from cells to mapped and paired receptor data visualized through our proprietary iPair Analyzer software.

Single cell sequencing and transcriptome profiling can be used to screen cancer patient samples for specific cellular biomarkers, such as PD1 and CTLA-4, to identify patients likely to respond in clinical trials. Single cell analysis can also be used to assess CAR-T cell therapy development, track cellular clonality and evaluate immune cell activation following antigen stimulation. High-resolution profiling may provide clues into patterns of variable immune cell activity and immunotherapy response.

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Questions about iPair single cell sequencing?

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Case Study

Cell therapy response

Learn how single cell TCR sequencing supports

  • Identify paired receptor sequences for downstream CAR-T development or validation purposes
  • Characterize progression-free survival following neoantigen treatment
  • Track expansion of tumor specific cytotoxic T cells
  • Explore the role of TCR diversity in improving clinical outcomes
See case study
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Ready to get started?

iPair/iPair + services

iRepertoire serves as a leader in the field of immune repertoire sequencing. We invite you to consult with our team of scientists to discover how iPair/iPair+ services can accelerate your analysis of immune cell function and diversity.

Schedule a consultation for single cell sequencing.

Let’s chat about your project