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Excerpt of Figure 1 from paper: Patients with lack of progression at 9 months have a higher peripheral TCR repertoire clonality prior to and throughout study treatment.

New study models TCR repertoire as a biomarker for immunotherapy response—reveals surprising signatures of PFS

Dec 14, 2020

Researchers at the Pittsburgh School of Medicine used a combination of RNA-seq and targeted immune sequencing to link a protein overexpressed within MPEs to reduced levels of T cell receptor (TCR) diversity

Finding new therapeutic targets in cancer research through changes in the immune adaptome

Nov 2, 2020

iPair automation in the clinical laboratory. Pipetting robot pipettes a grid of a tube rack.

Cue Biopharma uses iPair technology to demonstrate efficacy of Tumor Antigen-Specific T-Cell activating drug

Oct 29, 2020

Figure 3 Longitudinal analysis of TCR and BCR repertoires of four individuals. Samples were collected from three patients from early-mid stages after symptom onset (days 3, 5, 7, 12, 14) to the convalescent stage (days 17, 19). Samples from a healthy seasonal quadrivalent influenza vaccinee before and after vaccination (days 0, 4, 14, and 28) were used as a control. (A) The proportion of TCR-TRA, -TRB, -TRD, -TRG and BCR-IgH, -IgK, -IgL in the adaptive immune reservoirs. (B) Treemap plots representing unique CDR3 clonotypes in each of the seven chains on the indicated time points after symptom onset. The seven treemap plots each represent TCR-beta, -alpha, -delta, -gamma, and BCR-IgH, -IgK, -IgL. A rectangle in a treemap plot represents a unique clonotype. The size of a rectangle denotes the relative frequency of an individual CDR3 sequence, and the varying square size reflects areas of clonal expansion within the immune repertoire sampled. The color of the individual CDR3 sequence in each Treemap plot was randomly chosen, and thus, the colors do not precisely match between individual plots. From the left upper plot clockwise to the bottom plots: IgH, IgK, IgL, TRB, TRA, TRD, and TRG.

Scientists who discovered SARS just revealed a radar map of the immune system’s response to COVID-19

Oct 19, 2020

Translational Dx Virtual Summit Presentation: Predicting Treatment efficacy from FFPE-damaged tumor samples with immune repertoire profiling. Quantifiying response to cancer treatment via 7-chain immune repertoire sequencing

Translational Dx: Advances in Multi-Omic Oncology

Sep 9, 2020

Dr. Jian Han stands facing the camera in a polished white shirt, slightly smiled. Slightly blurred for the background is the view of an empty lab room at Hudson Alpha Institute for Biotechnology

Presentation from our Founder, Dr. Jian Han

Aug 31, 2020

Beckman Coulter COVID-19 Research Symposium

COVID-19 Research Symposium: Webinar

Jun 25, 2020

Blue-gloved hand holds up a PCR strip half filled with pink liquid, taking up most of the frame.

Launch of new viral RNA extraction solution with Beckman Coulter Life Sciences

May 18, 2020

White, beige, and blue glass, 4-5 story office building where iRepertoire is housed on the Hudson Alpha campus in Huntsville, Alabama

Screening local COVID-19 patient samples for antibodies

Apr 29, 2020

COVID-19 Science Spotlight on iRepertoire. See how iRepertoire, an industry leader in immune repertoire sequencing, is helping to combat COVID-19. Join speakers Miranda Byrne-Steele and Chelsea Berngruber in the YouTube LiveStream on March 1st, 2020 at 4:30 PM EST. Sponsored by Samba Scientific.

Sharing COVID-19 updates: Science Spotlight

Apr 22, 2020

Closeup of an astronaut with a closed helmet positioned on the right half of the image, looking accoss to the left. Helmet has a gold shimmer and background is a blurred white and grey

Rocket city scientists help in the fight against Coronavirus

Jan 31, 2020

SARS-CoV-2 virus medical illustration. 3D rendering of a close-up virus has a reddish pink base and blue and teal spike proteins. In the background, 3 more stylized viruses are blurred and smaller, in the distance.

Precision medicine workflow featuring RepSeq+ could help predict organ failure in COVID-19 patients

Jun 29, 2020

Watch the iRepertoire Labroots webinar

Webinar: Immune system NGS from single cell to bulk RNA

Mar 1, 2020

iRepertoire CEO Dennis Grimaud, a mid-aged man with silver hair, smiles at the camera wearing a black suitjacket and white collared shirt

Meet our new CEO

Feb 23, 2020

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