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Figure 3 Longitudinal analysis of TCR and BCR repertoires of four individuals. Samples were collected from three patients from early-mid stages after symptom onset (days 3, 5, 7, 12, 14) to the convalescent stage (days 17, 19). Samples from a healthy seasonal quadrivalent influenza vaccinee before and after vaccination (days 0, 4, 14, and 28) were used as a control. (A) The proportion of TCR-TRA, -TRB, -TRD, -TRG and BCR-IgH, -IgK, -IgL in the adaptive immune reservoirs. (B) Treemap plots representing unique CDR3 clonotypes in each of the seven chains on the indicated time points after symptom onset. The seven treemap plots each represent TCR-beta, -alpha, -delta, -gamma, and BCR-IgH, -IgK, -IgL. A rectangle in a treemap plot represents a unique clonotype. The size of a rectangle denotes the relative frequency of an individual CDR3 sequence, and the varying square size reflects areas of clonal expansion within the immune repertoire sampled. The color of the individual CDR3 sequence in each Treemap plot was randomly chosen, and thus, the colors do not precisely match between individual plots. From the left upper plot clockwise to the bottom plots: IgH, IgK, IgL, TRB, TRA, TRD, and TRG.

Scientists who discovered SARS just revealed a radar map of the immune system’s response to COVID-19

October 19, 2020

In this study, which was published in the journal Frontiers in Immunology on September 30th, researchers used sequencing to characterize the immune system of patients who survive from COVID-19 infection from symptom onset through recovery. Importantly, they also identified a potent biomarker for predicting disease progression. Follow-up studies could lead…

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Translational Dx: Advances in Multi-Omic Oncology

September 9, 2020

Watch the presentation now Join us at a new Virtual Summit, hosted by Samba Scientific. iRepertoire’s own Director of R&D and Operations Manager Miranda Byrne-Steele will present on September 23rd, followed by a live Q&A session. Sign up now for this new free summit on the latest advances in translational…

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Dr. Jian Han stands facing the camera in a polished white shirt, slightly smiled. Slightly blurred for the background is the view of an empty lab room at Hudson Alpha Institute for Biotechnology

Presentation from our Founder, Dr. Jian Han

August 31, 2020

State-of-the-art Infectious Disease Response In this presentation, our founder, Dr. Jian Han, discusses how iRepertoire’s technology has evolved from lessons learned through multiple epidemics to identify helpful antibodies with first-rate specificity, now using single-cell sequencing. Gain a personal overview of our pathway as a company, and an insider introduction to…

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SARS-CoV-2 virus medical illustration

COVID-19 Research Symposium: Webinar

June 25, 2020

Learn about our progress developing antibody-based therapies for SARS-CoV-2 in this presentation from Dr. Miranda Byrne-Steele, featured at Beckman Coulter Life Sciences’ COVID-19 Research Symposium. COVID-19 is very much a part of our lives today. Without herd immunity, we will need stopgap treatments to help patients fight SARS-CoV-2. We are…

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Rocket city scientists help in the fight against Coronavirus

January 31, 2020

iRepertoire is working with iCubate, our sister company in the Hudson Alpha Institute, to develop innovative solutions for combating the Coronavirus. On one side of the intervention strategy, iCubate is distributing diagnostic tests based on the same technology that powers the iR-Flex automation system. On the other side, iRepertoire will…

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SARS-CoV-2 virus medical illustration

Precision medicine workflow featuring RepSeq+ could help predict organ failure in COVID-19 patients

June 29, 2020

One of the biggest challenges in addressing COVID-19 has been the variability in the degree and type of symptoms that infected individuals have presented. Though it’s still unclear how to treat COVID-19 most effectively, one thing is certain: not all patients will require the same form or level of treatment.…

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COVID-19 response: research and testing

March 19, 2020

We are actively conducting research on COVID-19 with the goal of developing an antibody-based treatment. Additionally, we are maintaining limited laboratory operations in order to better serve our customers and collaborators who are doing their utmost in the fight against the pandemic. A message from our Founder, Dr. Jian Han…

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Webinar: Immune system NGS from single cell to bulk RNA

March 1, 2020

Labroots webinar featuring Dr. Miranda Byrne-Steele highlights iRepertoire’s newest technologies, dam-PCR and iPair. iPair is iRepertoire’s single cell repertoire sequencing service. In the webinar, Miranda explains how iPair retains the physical cognate pairing of B and T cell receptor chains. She also describes how iPair helps researchers probe the immune…

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iREP CEO Dennis Grimaud

Meet our new CEO

February 23, 2020

We’re excited to introduce our new CEO, Dennis Grimaud. Dennis Grimaud brings with him over 40 years of experience in the healthcare industry. Dennis has served as CEO for six different life science-related companies with focuses including business management, diagnostics, and disease management. He has also founded several companies and…

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Video: Learning from the best doctor in the world, our immune system

February 16, 2020

At the 2019 Gold Lab Symposium, iRertoire’s founder, Dr. Jian Han, explains what we can learn from a database of several billion B and T cell receptor sequences. The Gold Lab Symposium is an annual event that brings together leaders in their respective scientific fields that are committed to improving…

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